Fair warning. There were major spoilers released in this chat and I put them at the end. The first thing that I mention is big for all Knuckles fans, but especially those who are into the Chaotix, Julie-Su, Dark Legion, Brotherhood, Remington, Lara-Le, etc. This is a MUST read, after that, it's continue at your own risk.
KenPenders: Justin has been suggesting I take Knuckles retro back to his pre-series appearance. Not just his design, but the set-up as well. No Julie-Su, no guardians, no other characters that appeared in his series. I'd say the stories he wants would be along the lines of what we did in the Knuckles' Chaotix special. Nothing definite has been decided, but that's how the discussions have been going. What I want to do is reboot Knuckles 20 years later starting with issue #126. My thinking for this is that the longtime fans get the payoff of seeing where everything was going, while new readers could jump on without having to know the whole backstory. Not only would Lara-Su be a regular, but so would Knuckles' sibling. Actually, jumping 20 years later only puts you in the middle of an overall storyline I've had in mind since I was asked to develop Knuckles into a series. The second child would be shown in the 20 years later installments, tho not necessarily the early ones.
There you have it. The Knuckles series has two directions it can go after Sonic #125 and the one that is seemingly most likely to occur at the moment gets rid of every character from the Knux series (with the possible exception of the Chaotix--they may be spared). The rest of the stuff listed below from the chat are just the Knuckles spoilers/tid-bits (if you want some Sonic ones, check Sonic HQ ^_~), with some being bigger than others but nothing of the magnitude as a possible total wipe-out of the current Knuckles storyline after Sonic #125. The possibility has caused this...check it out if you're interested as it's started by a dedicated Knux fan over at the Sonic HQ boards.

KenPenders: Basically, we've locked in all the stroies for SONIC up to issue #125. #125 will be a full-length book. No 3 stories in that one.
KenPenders: Who is Kragok's son? Because I probably won't have the space to reveal it for a long time.... I'll answer that one here and now. It's Constable Remington. Only he doesn't know it...yet. Rem was raised in Echidnaopolis by his single mother. She was sworn to secrecy as Kragok didn't trust Lien-Da as far as his secrets went.
KenPenders: The one character I'd like to use in Knuckles is Crabmeat.
KenPenders: Knuckles will be red on a more or less permanenet basis by #125.
KenPenders: The Ultimate Power storyline will resolve whether [the UV is] Mammoth Mogul, Lien-Da or someone else
KenPenders: I gave Wynmacher his name, and I'd be hard pressed to tell you now where i got it from, or how I came up with it. I only remember i wanted something that sounded dignified for the character.
KenPenders: There's plenty of Julie-Su coming up, along with the Chaotix. Dawn just illustrated a story which shows Mighty's first meeting with Knux. They weren't really close buds back then. Also, Julie-Su and Vector will resolve their differences.
KenPenders: Lara-Su was from an alternate reality in [Reunification, Sonic #106-109].
KenPenders: Y'know, I'd love to push for more mini-series and stuff like that, but it ain't going to happen. Not in the current environment at least. Unless the publishers at Archie were convinced they could make more money than ever, that's why it won't happen. If I said anything about mini-series or specials, people would act like it was going to happen, so I don't want to be the one to get people's hopes up.
KenPenders: No Rouge-Knux relationship.
KenPenders: There is no official Archie SA2 beyond what appeared in #98.